Cesium carbonate → HCID 71542432, compound

Participants

Reaction Steps

5-bromo-N-(2-methyl-2H-tetrazol-5-yl)pyridine-2-amine (200 mg, 0.78 mmol), (R)-3-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-5-(hydroxylmethyl)oxazolidin-2-one (317 mg, 0.94 mmol), cesium carbonate (508 mg, 1.56 mmol) and Pd(dppf)Cl2 (90 mg, 0.16 mmol) were dissolved in 16 mL dioxane and 4 mL water, heated to 100° C. and reacted for 6 h. The solvent was evaporated to dryness, and the solid was separated by a silica gel column (dichloromethane:methanol=40:1) to obtain (R)-3-(3-fluoro-4-(6-((2-methyl-2H-tetrazol-5-yl)amino)pyridin-3-yl)phenyl)-5-(hydroxylmethyl)oxazolidin-2-one 90 mg, at a yield of 30%.

Provenance & Evidence