Water → HCID 71542528, compound

Participants

Reaction Steps

(R)-3-(3-fluoro-4-(6-((1-methyl-1H-tetrazol-5-yl)amino)pyridin-3-yl)phenyl)-5-(hydroxylmethyl)oxazolidin-2-one (200 mg, 0.52 mmol) was dissolved in 30 mL THF, and triethylamine (262 mg, 2.6 mmol) was added under ice-water bath. After half an hour, phosphorus oxychloride (397 mg, 2.6 mmol) was added, and reacted at room temperature for 12 h. Water (180 mg, 10 mmol) was added dropwise. After filtration, 140 mg of product was obtained, at a yield of 57%.

Provenance & Evidence