HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 86729998, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | HCID 77177338 | HCID 77177338 | — |
| Reactant | HCID 86729997 | HCID 86729997 | — |
| Catalyst | Water | HCID 962 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86729998 | HCID 86729998 | 152.9% |
Reaction Steps
5-bromo-N-(1-(methoxymethyl)-1H-1,2,3-triazol-4-yl)pyridine-2-amine (0.318 g, 1.119 mmol), 3-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-5-(hydroxylmethyl)oxazolidin-2-one (0.852 g, 2.527 mmol), sodium carbonate (0.357 g, 3.368 mmol), PdCl2(dppf)2 (0.064 g) were added into 20 mL dioxane and 2 drops of water, refluxed and reacted for 18 h under protection of nitrogen, cooled to room temperature, filtered, concentrated, chromatographed on a silica gel column (CH3OH:CH2Cl2=1:25), to obtain 0.709 g of crude 3-(3-fluoro-4-(6-((1-(methoxymethyl)-1H-1,2,3-triazol-4-yl)amino)pyridin-3-yl)phenyl)-5-(hydroxylmethyl)oxazolidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359344B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-fcf5eda620ff4c96bfe6c055f8f20aba |
| Source note | uspto-grants-2016_06 |