Hydrochloric Acid → HCID 178519200, compound

Participants

Reaction Steps

The crude 3-(3-fluoro-4-(6-((1-(methoxymethyl)-1H-1,2,3-triazol-4-yl)amino)pyridine-3-yl)phenyl)-5-(hydroxylmethyl)oxazolidin-2-one obtained in the last step was dissolved in 20 mL tetrahydrofuran. Into the solution were added 20 mL of 6 N hydrochloric acid and 4 mL of concentrated hydrochloric acid, and reacted and refluxed for 18 h. After concentration and chromatography on a silica gel column (CH3OH:CH2Cl2=1:50), a light yellow solid was obtained. Recrystallization from methanol yielded 70 mg of 3-(4-(6-((1H-1,2,3-triazol-4-yl)amino)pyridin-3-yl)-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one, at a yield over two steps of 16.9%.

Provenance & Evidence