Trifluoroacetic acid → HCID 90220317, compound

Participants

Reaction Steps

To a solution of {(R)-1-[4-cyano-5-(pyridin-2-ylamino)-thiazol-2-yl]-piperidin-3-yl}-carbamic acid tert-butyl ester (prepared as described in Example 1, Step 3) (20.2 mg, 50.4 μmol) in dichloromethane (0.5 mL) was added trifluoroacetic acid (1 mL, 13 mmol) and the mixture stirred under argon at ambient temperature for 30 minutes. The reaction mixture was concentrated in vacuo and the crude 2-((R)-3-amino-piperidin-1-yl)-5-(pyridin-2-ylamino)-thiazole-4-carbonitrile taken on to the next step in the synthesis without further purification.

Provenance & Evidence