反应详情

温度

79 °C

Acetonitrile (300 ml) and granular zinc (30.0 g) are combined in a 1 liter round bottomed flask and stirred at 75° C. under nitrogen as 4-(2-bromotetrafluoroethoxy)benzaldehyde (111.39 g, 0.37 mole) is added slowly by dropping addition funnel. The resulting mixture is stirred and heated at 79° C. for 12 hours. After filtration to remove zinc salts and unreacted zinc, the acetonitrile is removed under vacuum on a rotary evaporator. The resulting oily residue is flash distilled on a rotary evaporator under high vacuum (26.6 Pa) to provide 47.33 g (0.234 mole) of a water white oil in 63.3 percent yield.

1. additionis added slowly
2. additionaddition funnel
3. filtrationAfter filtration
4. customto remove zinc salts and unreacted zinc
5. customthe acetonitrile is removed under vacuum on a rotary evaporator
6. distillationdistilled on a rotary evaporator under high vacuum (26.6 Pa)