2'-Ethyl-2-(methoxymethyl)-[1,1'-biphenyl]-4-carboxylic acid → tert-butyl N-(5-{5-[2'-ethyl-2-(methoxymethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzyl)-N-methyl-beta-alaninate

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared following procedure described for example 141, step 1, but starting from Intermediate 36 (162.20 mg; 0.60 mmol) and Intermediate 63 (185.47 mg; 0.57 mmol), the crude mixture was purified by flash chromatography (c-hex/(DCM/EtOAc 1:1) gradient from 1:0 to 1:1) to afford the title compound as a colorless oil. 1H NMR (CDCl3) δ 8.42 (d, J=1.4 Hz, 1H), 8.23 (dd, J=7.1, 1.4 Hz, 1H), 8.17 (dd, J=7.9, 1.8 Hz, 1H), 8.12-8.08 (m, 1H), 7.41-7.10 (m, 6H), 4.27-4.17 (m, 2H), 3.66 (br s, 2H), 3.33 (s, 3H), 2.08 (t, J=7.0 Hz, 2H), 2.52-2.31 (m, 4H), 2.28 (s, 3H), 1.45 (s, 9H), 1.05 (t, J=7.5 Hz, 3H). LC/MS (Method B): 560.5 (M+H)+. HPLC (Method A) Rt 5.14 min (Purity: 94.0%).

Herkunft & Nachweise