反应详情

The title compound was prepared following procedure described for example 141, step 1, but starting from Intermediate 56 (134.55 mg; 0.60 mmol) and Intermediate 60 (177.47 mg; 0.57 mmol), the crude mixture was purified by flash chromatography (c-hex/(DCM/EtOAc 1:1) gradient from 1:0 to 1:1) to afford the title compound as a colorless oil. 1H NMR (CDCl3) δ 8.24-8.20 (m, 2H), 8.11-8.04 (m, 2H), 7.17 (t, J=9.0 Hz, 1H), 6.98 (d, J=8.8 Hz, 1H), 4.70 (quint., J=6.1 Hz, 1H), 4.54 (s, 2H), 3.89 (s, 2H), 3.50 (s, 3H), 3.27 (s, 2H), 2.46 (s, 3H), 1.51 (s, 9H), 1.40 (d, J=6.0 Hz, 6H). LC/MS (Method B): 500.4 (M+H)+. HPLC (Method A) Rt 4.44 min (Purity: 97.6%).

1. customThe title compound was prepared following procedure
2. customthe crude mixture was purified by flash chromatography (c-hex/(DCM/EtOAc 1:1) gradient from 1:0 to 1:1)