Hydrochloric Acid → HCID 131729781, compound

Participants

Reaction Steps

Tert-butyl (2-fluoro-4-{5-[3-(methoxymethyl)-4-(2-methylpiperidin-1-yl)phenyl]-1,2,4-oxadiazol-3-yl}phenoxy)acetate (340 mg, 0.66 mmol) was dissolved in a 4M solution of HCl in dioxane (4 mL). The resulting mixture was stirred at RT for 15 hours. The precipitate was filtered off, washed with Et2O (3×) and pentane (3×), then dried under reduced pressure to give the title compound an as white powder (287 mg, 88%). 1HNMR (DMSO-d6, 300 MHz): 8.18 (brs, 1H), 8.07 (brs, 1H), 7.86 (m, 2H), 7.40 (brs, 1H), 7.30 (dd, J=8.6, 8.5 Hz, 1H), 4.91 (s, 2H), 4.58 (brs, 2H), 3.41 (s, 3H), 3.26 (m, 1H), 3.07 (m, 1H), 2.65 (m, 1H), 1.84-1.47 (m, 6H), 0.87 (brs, 3H). LC/MS (Method A): 456.3 (M+H)+; 454.4 (M−H)−. HPLC (Method A) Rt: 3.42 min (Purity: 99.7%).

Provenance & Evidence