2,6-Dimethylbenzyl Chloride → HCID 68184346, compound

HRID 2199913Notes

Reaction equation

HRID 2199913 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1.[CH3:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:16]=1[CH2:17]Cl.C(N1C2C(=CC=C(C(O)=O)C=2)C=C1)C1C=CC=CC=1>>[CH3:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:16]=1[CH2:17][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1

Participants

4

Reactant 3

HCID 2211542,6-Dimethylbenzyl ChlorideHCID 639844Methyl indole-6-carboxylateHCID 179478751-benzyl-1H-indole-6-carboxylic acid

Product 1

HCID 68184346HCID 68184346, compoundYield 88.4%

Procedure

The titled compound (7.4 g) as a white solid was prepared from methyl indole-6-carboxylate (5.0 g) and 2,6-dimethylbenzyl chloride (5.3 g) according to the method of the process (1) of Example 1.

Sources & evidence

ORD record
ord-b6ae47dce5794da8b42b69a95c41e7d5
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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