4-Fluoro-2-(trifluoromethyl)benzyl bromide → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199930Notes

Reaction equation

HRID 2199930 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[CH2:14]([N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([CH2:30][C:31]([OH:33])=[O:32])[CH:28]=2)[CH:23]=[CH:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:21]2[C:29]3[C:24](=[CH:25][CH:26]=[C:27]([CH2:30][C:31]([OH:33])=[O:32])[CH:28]=3)[CH:23]=[CH:22]2)=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[CH2:14]([N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([CH2:30][C:31]([OH:33])=[O:32])[CH:28]=2)[CH:23]=[CH:22]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 27375764-Fluoro-2-(trifluoromethyl)benzyl bromideHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184212HCID 68184212, compound

Procedure

The titled compound (36 mg) as a reddish brown solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 4-fluoro-2-(trifluoromethyl)benzyl bromide according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-9144e56ebbb148228263a564d274d69d
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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