Potassium Carbonate → HCID 68183782, compound

Participants

Reaction Steps

To a solution of 5-benzoimidazole carboxylic acid (1.1 g) in N,N-dimethylformamide (15 mL) were added potassium carbonate (2.7 g) and 2,6-dimethylbenzyl chloride (2.3 g) at room temperature, and then the reaction mixture was stirred at room temperature for 2 days. The reaction mixture was quenched with water, and extracted with chloroform. The obtained organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give the titled compound (1.1 g) as a white solid.

Provenance & Evidence