Potassium Hydroxide → potassium 1-(2,6-dimethylbenzyl)-3-methyl-1H-indole-6-carboxylate

HRID 2199959Notes

Reaction equation

HRID 2199959 reaction equation
[CH3:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([OH:16])=[O:15])[CH:12]=2)[C:7]([CH3:17])=[CH:6]1.[OH-].[K+:24]>C(O)C>[CH3:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([O-:16])=[O:15])[CH:12]=2)[C:7]([CH3:17])=[CH:6]1.[K+:24]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 601520061-(2,6-dimethylbenzyl)-3-methyl-1H-indole-6-carboxylic acid

Product 1

HCID 131735704potassium 1-(2,6-dimethylbenzyl)-3-methyl-1H-indole-6-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound [61] (2.1 g) in ethanol (20 mL) was added an aqueous solution of 1N-potassium hydroxide (7.1 mL) at room temperature, and the solution was concentrated under reduced pressure to give the titled compound (2.4 g) as a yellow solid.

Workup

  1. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-74ab582f2d784ab4a10ed5fa7dde9fb4
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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