Potassium Carbonate → HCID 60152150, compound

Participants

Reaction Steps

To a solution of the compound obtained in the process (3) of Example 64 [64-3] (272 mg) in N-methyl-2-pyrrolidone (4 mL) were added potassium carbonate (555 mg) and 2,6-dichlorobenzyl chloride (516 mg) at room temperature, and then the reaction mixture was subjected to microwave irradiation at 130° C. for 40 minutes. The reaction mixture was quenched with water, and extracted with ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give a brown oil. The obtained oil was dissolved in tetrahydrofuran (2 mL) and methanol (2 mL). 3N-sodium hydroxide (1 mL) was added at room temperature, and then the reaction mixture was subjected to microwave irradiation at 160° C. for 10 minutes. The reaction mixture was quenched with water, and extracted with ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give the titled compound (194 mg) as a white solid.

Provenance & Evidence