Benzene, 2-(chloromethyl)-1,4-dimethyl- → HCID 68184380, compound

HRID 2199977Notes

Reaction equation

HRID 2199977 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:12][C:13]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:14]=1[CH2:15]Cl.C(N1C2C(=CC=C(C(O)=O)C=2)C=C1)C1C=CC=CC=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][N:8]2[CH2:15][C:14]2[CH:17]=[C:18]([CH3:21])[CH:19]=[CH:20][C:13]=2[CH3:12])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 69987Benzene, 2-(chloromethyl)-1,4-dimethyl-HCID 179478751-benzyl-1H-indole-6-carboxylic acidHCID 178434209HCID 178434209, compound

Product 1

HCID 68184380HCID 68184380, compoundYield 68.4%

Procedure

The titled compound (158 mg) as a white solid was prepared from 6-bromo-3-methyl-1H-indazole (148 mg) obtained with the method described in the document (JP 2009-528363 W) and 2,5-dimethylbenzyl chloride (164 mg) according to the method of the process (1) of Example 66.

Workup

  1. customobtained with the method

Sources & evidence

ORD record
ord-2e394d47980047c8910833ef0cd949a5
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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