3-(Bromomethyl)-5-chloro-1-benzothiophene → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199980Notes

Reaction equation

HRID 2199980 reaction equation
Br[CH2:2][C:3]1[C:4]2[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:5]=2[S:6][CH:7]=1.Cl[C:14]1[CH:34]=[CH:33][CH:32]=[C:31](C)[C:15]=1[CH2:16][N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[C:19]([CH3:30])=[N:18]1>>[Cl:12][C:10]1[CH:9]=[CH:8][C:5]2[S:6][CH:7]=[C:3]([CH2:2][N:17]3[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=4)[C:19]([CH3:30])=[N:18]3)[C:4]=2[CH:11]=1.[CH2:16]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:30]1)[C:15]1[CH:14]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 27798573-(Bromomethyl)-5-chloro-1-benzothiopheneHCID 60152152HCID 60152152, compound

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184283HCID 68184283, compound

Procedure

The titled compound (4.3 mg) as a brown solid was prepared from the compound [102-4] obtained in the process (4) of Example 102 (24.7 mg) and 3-bromomethyl-5-chlorobenzo[b]thiophene according to the method of the process (5) of Example 102.

Sources & evidence

ORD record
ord-d5cc1a0272f34b98815b049e060f0601
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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