1-Chloromethylnaphthalene → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199981Notes

Reaction equation

HRID 2199981 reaction equation
Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.Cl[C:14]1[CH:34]=[CH:33][CH:32]=[C:31](C)[C:15]=1[CH2:16][N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[C:19]([CH3:30])=[N:18]1>>[CH3:30][C:19]1[C:20]2[C:25](=[CH:24][C:23]([CH2:26][C:27]([OH:29])=[O:28])=[CH:22][CH:21]=2)[N:17]([CH2:2][C:3]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH:6]=[CH:5][CH:4]=2)[N:18]=1.[CH2:16]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:30]1)[C:15]1[CH:14]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 68451-ChloromethylnaphthaleneHCID 60152152HCID 60152152, compound

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184446HCID 68184446, compound

Procedure

The titled compound (19.5 mg) as a white solid was prepared from the compound [102-4] obtained in the process (4) of Example 102 (26.3 mg) and 1-(chloromethyl)naphthalene according to the method of the process (5) of Example 102.

Sources & evidence

ORD record
ord-2a682f6d2bd7440f81bd65cd8b807e69
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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