1-Chloro-2-phenylethane → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199984Notes

Reaction equation

HRID 2199984 reaction equation
ClCCC1C=CC=CC=1.Cl[C:11]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:12]=1[CH2:13][N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24]([OH:26])=[O:25])[CH:21]=2)[C:16]([CH3:27])=[N:15]1>>[CH3:27][C:16]1[C:17]2[C:22](=[CH:21][C:20]([CH2:23][C:24]([OH:26])=[O:25])=[CH:19][CH:18]=2)[N:14]([CH2:13][CH2:12][C:11]2[CH:32]=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:15]=1.[CH2:13]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24]([OH:26])=[O:25])[CH:21]=2)[CH:16]=[CH:27]1)[C:12]1[CH:11]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 2314961-Chloro-2-phenylethaneHCID 60152152HCID 60152152, compound

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68183979HCID 68183979, compound

Procedure

The titled compound (1.9 mg) as a white solid was prepared from the compound [102-4] obtained in the process (4) of Example 102 (42.6 mg) and (2-chloroethyl)benzene according to the method of the process (5) of Example 102.

Sources & evidence

ORD record
ord-5ab6fc96029045698246ad5d89d2d6c2
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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