8-(Bromomethyl)quinoline → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199985Notes

Reaction equation

HRID 2199985 reaction equation
Br[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[CH:8]2.Cl[C:14]1[CH:34]=[CH:33][CH:32]=[C:31](C)[C:15]=1[CH2:16][N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[C:19]([CH3:30])=[N:18]1>>[CH3:30][C:19]1[C:20]2[C:25](=[CH:24][C:23]([CH2:26][C:27]([OH:29])=[O:28])=[CH:22][CH:21]=2)[N:17]([CH2:2][C:3]2[CH:4]=[CH:5][CH:6]=[C:7]3[C:12]=2[N:11]=[CH:10][CH:9]=[CH:8]3)[N:18]=1.[CH2:16]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:30]1)[C:15]1[CH:14]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 3469148-(Bromomethyl)quinolineHCID 60152152HCID 60152152, compound

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184284HCID 68184284, compound

Procedure

The titled compound (73.8 mg) as a yellow solid was prepared from the compound [102-4] obtained in the process (4) of Example 102 (102 mg) and 8-(bromomethyl)quinoline according to the method of the process (5) of Example 102.

Sources & evidence

ORD record
ord-bf1c0df0e4cc485cb7d375b4415fff00
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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