Potassium Hydroxide → HCID 131732624, compound

HRID 2199986Notes

Reaction equation

HRID 2199986 reaction equation
[CH3:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([OH:16])=[O:15])[CH:12]=2)[C:7]([CH3:17])=[N:6]1.[OH-].[K+:24]>C(O)C>[CH3:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([O-:16])=[O:15])[CH:12]=2)[C:7]([CH3:17])=[N:6]1.[K+:24]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 68184383HCID 68184383, compound

Product 1

HCID 131732624HCID 131732624, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound [117] (568 mg) in ethanol (20 mL) was added an aqueous solution of 1N-potassium hydroxide (1.93 mL) at room temperature, and then the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to give the titled compound (636 mg) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d42d61bbc30b4914841907db71924fb5
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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