Potassium Hydroxide → HCID 131732627, compound

HRID 2200000Notes

Reaction equation

HRID 2200000 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([F:19])([F:18])[C:15]([OH:17])=[O:16])[CH:12]=2)[C:7]([CH3:20])=[N:6]1.[OH-].[K+:27]>C(O)C>[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([F:19])([F:18])[C:15]([O-:17])=[O:16])[CH:12]=2)[C:7]([CH3:20])=[N:6]1.[K+:27]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 68184408HCID 68184408, compound

Product 1

HCID 131732627HCID 131732627, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound [183] (89 mg) in ethanol (2 mL) was added an aqueous solution of 1N-potassium hydroxide (233 μL) at room temperature, and then the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to give the titled compound (98 mg) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-15126edf20854ae2bbab38187d6fa0b9
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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