(5-(Cyano-dimethyl-methyl)-2-{3-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-phenyl}-2H-pyrazol-3-yl)-carbamic acid 2,2,2-trichloro-ethyl ester → HCID 117729467, compound

Participants

Reaction Steps

Intermediate 20d (375 mg, 0.69 mmol) was dissolved in MeOH (5 mL) and loaded onto a 20 g SCX-2 SPE cartridge (pre-conditioned with MeOH). The cartridge was then washed with MeOH (2 column volumes) and the eluent concentrated in vacuo to afford the title compound as a colorless oil (283 mg, 89%). LCMS (Method 3): Rt 3.71 min, m/z 461, 463 [MH+].

Provenance & Evidence