1-{5-(Cyano-dimethyl-methyl)-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea → Methanesulfonic acid 2-{3-[3-(cyano-dimethyl-methyl)-5-(3-{(1S,4R)-4-[3-((S)-2-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-ureido)-pyrazol-1-yl]-phenoxy}-ethyl ester
Reaction equation
[C:1]([C:3]([CH3:51])([CH3:50])[C:4]1[CH:5]=[C:6]([NH:19][C:20]([NH:22][C@@H:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[C@H:26]([O:33][C:34]3[CH:35]=[CH:36][C:37]4[N:38]([C:40]([N:43]5[CH2:48][CH2:47][CH2:46][CH2:45][C@@H:44]5[CH3:49])=[N:41][N:42]=4)[CH:39]=3)[CH2:25][CH2:24]2)=[O:21])[N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][CH2:17][OH:18])[CH:10]=2)[N:8]=1)#[N:2].C[C@H]1CCC[C@@H](C)N1C1N2C=C(O[C@H]3C4C(=CC=CC=4)[C@@H](NC(=O)NC4N(C5C=NN(CC[O:95][S:96]([CH3:99])(=O)=[O:97])C=5)N=C(C(C)C)C=4)CC3)C=CC2=NN=1>>[C:1]([C:3]([CH3:50])([CH3:51])[C:4]1[CH:5]=[C:6]([NH:19][C:20]([NH:22][C@@H:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[C@H:26]([O:33][C:34]3[CH:35]=[CH:36][C:37]4[N:38]([C:40]([N:43]5[CH2:48][CH2:47][CH2:46][CH2:45][C@@H:44]5[CH3:49])=[N:41][N:42]=4)[CH:39]=3)[CH2:25][CH2:24]2)=[O:21])[N:7]([C:9]2[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=2)[O:15][CH2:16][CH2:17][O:18][S:96]([CH3:99])(=[O:97])=[O:95])[N:8]=1)#[N:2]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared using Intermediate 20f in an analogous fashion to the procedures described for Intermediate A step e. LCMS (Method 3): Rt 3.64 min, m/z 768.5 [MH+].
Sources & evidence
- ORD record
- ord-d5eb9f982f784bc5b53cfbd6de0826c0
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09359354B2
Reaction notes
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