(1S,4R)-4-[3-(cis-2,6-Dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-ylamine → 1-{5-(Cyano-dimethyl-methyl)-2-[3-(2-hydroxy-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-((2S,6R)-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea
Reaction equation
ClC(Cl)(Cl)CO[C:5](=[O:27])[NH:6][C:7]1[N:8]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][CH2:25][OH:26])[CH:18]=2)[N:9]=[C:10]([C:12]([C:15]#[N:16])([CH3:14])[CH3:13])[CH:11]=1.[CH3:30][C@H:31]1[CH2:36][CH2:35][CH2:34][C@@H:33]([CH3:37])[N:32]1[C:38]1[N:42]2[CH:43]=[C:44]([O:47][C@H:48]3[C:57]4[C:52](=[CH:53][CH:54]=[CH:55][CH:56]=4)[C@@H:51]([NH2:58])[CH2:50][CH2:49]3)[CH:45]=[CH:46][C:41]2=[N:40][N:39]=1.C[C@H]1CCC[C@@H](C)N1C1N2C=C(O[C@H]3C4C(=CC=CC=4)[C@@H](NC(=O)NC4N(C5C=NN(CCOS(C)(=O)=O)C=5)N=C(C(C)C)C=4)CC3)C=CC2=NN=1>>[C:15]([C:12]([CH3:14])([CH3:13])[C:10]1[CH:11]=[C:7]([NH:6][C:5]([NH:58][C@@H:51]2[C:52]3[C:57](=[CH:56][CH:55]=[CH:54][CH:53]=3)[C@H:48]([O:47][C:44]3[CH:45]=[CH:46][C:41]4[N:42]([C:38]([N:32]5[C@H:31]([CH3:30])[CH2:36][CH2:35][CH2:34][C@@H:33]5[CH3:37])=[N:39][N:40]=4)[CH:43]=3)[CH2:49][CH2:50]2)=[O:27])[N:8]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][CH2:25][OH:26])[CH:18]=2)[N:9]=1)#[N:16]Participants
4
Reactant 3
Product 1
Procedure
The title compound was prepared using Intermediate 20e and Intermediate 3 in an analogous fashion to the procedure described for Intermediate A step d. LCMS (Method 3): Rt 3.61 min, m/z 704.5 [MH+].
Sources & evidence
- ORD record
- ord-8522c19be8174de0b2792539c7de6041
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09359354B2
Reaction notes
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