Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 58019866 | HCID 58019866 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 58019861 | HCID 58019861 | — |
Reaction Steps
Sodium methoxide is generated by reaction of sodium metal (81 mg) in dry methanol (30 mL). The product of example 4 (700 mg) is dissolved in dry dimethoxyethane and the temperature raised to 100° C. After overnight reaction, the mixture is concentrated in vacuo and the residue is chromatographed on silica using 5% methanol in dichloromethane. Yield 120 mg. NMR is consistent with structure assignment.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09359360B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-db990e5aa4d24bf1be0b5ae186e43d3f |
|---|
| Source note | uspto-grants-2016_06 |
|---|
