Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → HCID 76072303, compound

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Reaction Steps

(4-(4-(Trifluoromethyl)phenyl)morpholin-2-yl)methylamine hydrochloride (99 mg, 0.34 mmol), 2-[(4-fluoro-benzenesulfonyl)-isopropyl-amino]-acetic acid (96 mg, 0.35 mmol), BOP reagent (154 mg, 0.35 mmol) and TEA (0.2 mL) were combined in 5 mL of dichloromethane. The mixture was stirred overnight and solvents were evaporated. The residue was extracted with ethyl acetate and water. The organic layer was washed with sodium bicarbonate solution and dried. Solvents were evaporated and the residue was purified by ISCO flash column chromatography (11 g silica gel, ethyl acetate in hexanes 0% to 50%) to give the desired compound as a white solid (133 mg, 74%). [MH]+=517.9.

Provenance & Evidence