Hydrochloric Acid → HCID 90020562, compound

Participants

Reaction Steps

Add 1M HCl aqueous solution (10 mL) to a solution of the imine obtained in Step 3 (450 mg, 1.0 mmol) in THF (10 mL), stir the reaction at room temperature for 1 hr. Basicify with saturated NaHCO3 solution, extract with EtOAc (30 mL×2). Combine the organic layers, dry over anhydrous Na2SO4. Concentration and purification by chromatography (silica gel, EtOAc:PE=1:1) afford the title compound (230 mg, 80.8%). MS: (M+1): 285.2.

Provenance & Evidence