N-(6-(4-nitrophenoxy)pyrimidin-4-yl)cyclopropanecarboxamide → HCID 90020621, compound

Participants

Reaction Steps

Dissolve N-[6-(4-nitrophenoxyl)pyrimidin-4-yl]cyclopropanecarboxamide (2.2 g, 7.33 mmol) in DCM (50 mL), add Pd/C (10%, 340 mg), flush with H2, and stir at room temperature under H2 for 2 hrs. After the reaction is complete, flush with N2, and then filter, concentrate the filtrate, purify the crude product by chromatography (silica gel, EtOAc:PE=1:1) to provide the title compound (1.8 g, 91%). MS: (M+1): 271.

Provenance & Evidence