HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 90019760, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-3-methyl-5-nitropyridine | HCID 89648 | — |
| Reactant | HCID 178507942 | HCID 178507942 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 90019760 | HCID 90019760 | 45% |
Reaction Steps
Mix 2-aminopyridin-4-ol (3.3 g, 30 mmol), 2-chloro-3-methyl-5-nitropyridine (5.17 g, 30 mmol) in anhydrous DMF (50 mL), add K2CO3 (8.28 g, 60 mmol). Stir the reaction at 90° C. overnight. Concentrate under reduced pressure to give crude product. Purification by chromatography (silica gel, EtOAc:PE=1:1) affords the title compound (3.3 g, 45%). MS: (M+1): 247.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-2d4c080a63a3481b80d9c57e47d87828 |
| Source note | uspto-grants-2016_06 |