HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 118223449, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Methylcyclopropane-1-carbonyl chloride | HCID 12789939 | — |
| Reactant | 2-Amino-4-(2-fluoro-4-nitrophenoxy)pyridine | HCID 23153198 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 118223449 | HCID 118223449 | 24% |
Reaction Steps
Add the solution of the above 1-methylcyclopropanecarbonyl chloride in DCM slowly to a solution of 4-(2-fluoro-4-nitro-phenoxy)pyridin-2-amine (500 mg, 2.0 mmol) and Et3N (505 mg, 5.0 mmol) in DCM (15 mL) at 0° C. Stir the reaction at room temperature for 15 hrs. TLC (EtOAc:PE=1:1) shows the reaction is complete. Concentrate the mixture to give the crude product. Purification by chromatography (silica gel, EtOAc:PE=1:1) affords the target compound (160 mg, 24%). MS: (M+1): 332.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-a69d4a5d81f84ea8b56f7127211c1ab4 |
| Source note | uspto-grants-2016_06 |