HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride → {3-(4-Ethylphenyl)-5-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}(thiomorpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride | HCID 4390391 | — |
| Reactant | 5-(4-Ethylphenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58116464 | — |
| Product | {3-(4-Ethylphenyl)-5-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}(thiomorpholin-4-yl)methanone | HCID 59606581 | — |
Reaction Steps
According to General Method 6A, 300 mg (0.828 mmol) of the compound from Example 7A and 134 mg (0.910 mmol) of N′-hydroxy-3-methoxypropanimidamide were reacted Yield: 185 mg (49% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202862B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-77fe6d54c35842a69c03cfcf2e6dd501 |
| Source note | uspto-grants-2012_06 |