HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (3-Bromo-5-(trifluoromethyl)phenyl)(piperidin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | HCID 90029693 | HCID 90029693 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3-Bromo-5-(trifluoromethyl)phenyl)(piperidin-4-yl)methanone | HCID 90020499 | 135.2% |
Reaction Steps
Add trifluoroacetic acid in dichloromethane (20%, 5 mL) to the solution of tert-butyl-4-(3-bromo-5-(trifluoromethyl)benzoyl)piperidine-1-carboxylate (387 mg, 0.88 mmol) in dichloromethane (5 mL) at 0° C., stir the mixture. TLC (PE:EtOAc=5:1) shows the reaction is complete. Concentrate under reduced pressure to dryness to afford the crude product (400 mg, 100%) which is used directly in next step. MS: (M+1): 336.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-4ed2c7f96a894190aa2ce5e345bb2ad7 |
| Source note | uspto-grants-2016_06 |