HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → (3-Bromo-5-(trifluoromethyl)phenyl)(1-methylpiperidin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | (3-Bromo-5-(trifluoromethyl)phenyl)(piperidin-4-yl)methanone | HCID 90020499 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | (3-Bromo-5-(trifluoromethyl)phenyl)(1-methylpiperidin-4-yl)methanone | HCID 90020609 | 77% |
Reaction Steps
Stir the mixture of (3-bromo-5-(trifluoromethyl)phenyl)(piperidin-4-yl)methanone (400 mg, 0.96 mmol), formic acid (1 mL) and formaldehyde (1 mL) at 100° C. overnight. Upon the reaction completion, concentrate under reduced pressure to provide the crude product (250 mg, 77%) which is used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-5cae838b1bee4480b317dd5d8954ac40 |
| Source note | uspto-grants-2016_06 |