HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Methyl 3-nitro-5-(trifluoromethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Nitro-5-(trifluoromethyl)benzoic acid | HCID 616602 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-nitro-5-(trifluoromethyl)benzoate | HCID 18942157 | 100% |
Reaction Steps
Add thionyl chloride (2 mL) dropwise to the solution of 3-nitro-5-(trifluoromethyl)benzoic acid (1.5 g, 6.4 mmol) in methanol (20 mL), reflux for 5 hrs. TLC (PE:EtOAc=1:1) shows the reaction is complete. Concentrate under reduced pressure to give the crude product (1.8 g, 100%) which is used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-257422235d964f9abf47e5d1eb569a7b |
| Source note | uspto-grants-2016_06 |