HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide → N-(3-amino-5-(trifluoromethyl)phenyl)-2-methoxyacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide | HCID 90020182 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(3-amino-5-(trifluoromethyl)phenyl)-2-methoxyacetamide | HCID 90020420 | 100% |
Reaction Steps
Add Pd/C (10%, 30 mg) to the solution of 2-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide (100 mg, 0.36 mmol) in methanol (6 mL), stir the mixture under hydrogen atmosphere at room temperature for 16 hrs. Filter off the solid, concentrate the filtrate under reduced pressure to yield the crude product (89 mg, 100%) which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-b07614988f5e48d597e7a8a99a8c4906 |
| Source note | uspto-grants-2016_06 |