HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-1-(3-nitro-5-(trifluoromethyl)phenyl)piperidine → 3-(4-Fluoropiperidin-1-yl)-5-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-1-(3-nitro-5-(trifluoromethyl)phenyl)piperidine | HCID 90020612 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-Fluoropiperidin-1-yl)-5-(trifluoromethyl)aniline | HCID 90032616 | 103% |
Reaction Steps
Add Pd/C (10%, 70 mg) to the solution of 4-fluoro-1-(3-nitro-5-(trifluoromethyl)phenyl)piperidine (300 mg, 1.0 mmol) in methanol (10 mL), stir the mixture under hydrogen atmosphere for 16 hrs at room temperature. Filter and concentrate the filtrate to get the crude product (270 mg, 100%) which is used directly without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-2f79a566dcc744149cf248499c1f9948 |
| Source note | uspto-grants-2016_06 |