HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 1-Methyl-4-[[3-nitro-5-(trifluoromethyl)phenyl]methyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1-(Chloromethyl)-3-nitro-5-(trifluoromethyl)benzene | HCID 68425095 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Methyl-4-[[3-nitro-5-(trifluoromethyl)phenyl]methyl]piperazine | HCID 58902366 | 100% |
Reaction Steps
Stir the mixture of 1-(chloromethyl)-3-nitro-5-(trifluoromethyl)benzene (640 mg, 2.68 mmol) and N-methylpiperazine (536 mg, 5.36 mmol) in THF (8 mL) for 2 hrs at 60° C. TLC (EtOAc:PE=1:1) shows the reaction is complete. Concentrate the reaction mixture under reduced pressure to obtain the crude product (812 mg, 100%). MS: (M+1): 303.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-910e5f43cdc44a3db6714126dc657e98 |
| Source note | uspto-grants-2016_06 |