HCID 90020473, compound → HCID 90019788, compound

HRID 2200153Notes

Reaction equation

HRID 2200153 reaction equation
[F:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([N+:20]([O-])=O)[CH:11]=2)[CH2:6][CH2:5]1>CO.[Pd]>[F:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:11]=[C:12]([CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:15]=2)[NH2:20])[CH2:6][CH2:5]1

Participants

4

Reactant 1

HCID 90020473HCID 90020473, compound

Product 1

HCID 90019788HCID 90019788, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Stir the mixture of 1-(2-fluoroethyl)-4-(3-nitro-5-(trifluoromethyl)phenyl)piperazine (120 mg, 0.50 mol) and Pd/C (10%, 30 mg) in methanol (5 mL) under hydrogen atmosphere for 2 hrs at room temperature. Filter and concentrate the filtrate under reduced pressure to afford the white solid as the target compound (90 mg, 84%).

Workup

  1. filtrationFilter
  2. concentrationconcentrate the filtrate under reduced pressure

Sources & evidence

ORD record
ord-0b542f8e66e64179a6de604ca431d5e6
Source dataset
uspto-grants-2016_06
Patent number
US09359338B2

Reaction notes

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