HCID 90029300, compound → HCID 118223408, compound

HRID 2200172Notes

Reaction equation

HRID 2200172 reaction equation
[CH:1]1([N:4]2[CH2:9][CH:8]=[C:7]([C:10]3[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([N+:20]([O-])=O)[CH:11]=3)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1>CO.[Pd]>[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]3[CH:11]=[C:12]([CH:13]=[C:14]([C:16]([F:19])([F:17])[F:18])[CH:15]=3)[NH2:20])[CH2:6][CH2:5]2)[CH2:2][CH2:3]1

Participants

4

Reactant 1

HCID 90029300HCID 90029300, compound

Product 1

HCID 118223408HCID 118223408, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Stir the mixture of Pd/C (10%, 30 mg), 1-cyclopropyl-4-(3-nitro-5-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine (120 mg 0.32 mmol) in methanol (10 mL) under hydrogen atmosphere at room temperature for 18 hrs. Remove hydrogen atmosphere, filter off the solid, concentrate the filtrate to yield the product as a white solid (85 mg, 94%). MS: (M+1): 285.1.

Workup

  1. filtrationRemove hydrogen atmosphere, filter off the solid
  2. concentrationconcentrate the filtrate

Sources & evidence

ORD record
ord-663d5616822b41008a24f8675aaa9cae
Source dataset
uspto-grants-2016_06
Patent number
US09359338B2

Reaction notes

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