Pyridine → HCID 118223422, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve the compound obtained in Step 2 (2.9 g, 10.61 mmol) in THF (30 mL), cool to −30° C., then add pyridine (1.68 g, 21.22 mmol) and phenyl chloroformate (1.83 g, 11.67 mmol). Stir at room temperature for 3 hrs. TLC (DCM:MeOH=10:1) shows the reaction is complete. Pour the solution to a mixture of EtOAc and water, separate the organic layer, and wash with brine, dry over anhydrous Na2SO4. Concentrate under reduced pressure to give the crude product (4.3 g). MS: (M+1): 394.1.

Provenance & Evidence