HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[3-nitro-5-(trifluoromethyl)phenyl]methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 3-Nitro-5-(trifluoromethyl)aniline | HCID 2775709 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[3-nitro-5-(trifluoromethyl)phenyl]methanesulfonamide | HCID 68424558 | 36.4% |
Reaction Steps
Dissolve 3-nitro-5-(trifluoromethyl)aniline (300 mg, 1.45 mmol) in DCM (5 mL), add triethylamine (294 mg, 2.9 mmol) and then methylsulfonyl chloride (182 mg, 1.6 mmol). Stir the reaction at room temperature for 17 hrs. TLC (EtOAc:PE=1:3) shows the reaction is complete. Concentrate under reduced pressure to afford the crude product. Purification by chromatography (silica gel, EtOAc:PE=3:7) affords the title compound (150 mg, 36%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-72b42db2044b4c508d5ec71873d3731d |
| Source note | uspto-grants-2016_06 |