HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 1-[6-Chloro-4-(trifluoromethyl)-2-pyridinyl]-4-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,6-Dichloro-4-(trifluoromethyl)pyridine | HCID 520968 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[6-Chloro-4-(trifluoromethyl)-2-pyridinyl]-4-methylpiperazine | HCID 90020245 | 91% |
Reaction Steps
Dissolve 2,6-dichloro-4-(trifluoromethyl)pyridine (215 mg, 1 mmol) and DIEA (129 mg, 1 mmol) in DMF (2 mL), add 1-methyl piperazine (100 mg, 1 mmol). Stir the reaction at 120° C. overnight. Cool to room temperature; concentrate under reduced pressure to give the crude product. Purification by chromatography (silica gel, MeOH:DCM=1:10) affords the product (253 mg, 91%). MS: (M+1): 280.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-fa8e4b37bd45471b8374175316865f2c |
| Source note | uspto-grants-2016_06 |