Cesium carbonate → HCID 90020436, compound

Participants

Reaction Steps

Add the compound obtained in Step 1 (1.21 g, 6.81 mmol), benzophenone imine (1.83 g, 10.22 mmol), Cs2CO3 (4.43 g, 13.6 mmol) to 1,4-dioxane (15 mL), then under N2, add BINAP (635 mg, 1.02 mmol), Pd2(dba)3 (623 mg, 0.68 mmol), stir the reaction at 120° C. under N2 atmosphere for 15 hrs. Cool to room temperature; filter off the solid, concentrate the filtrate under reduced pressure to give a crude residue. Purification by chromatography (silica gel, EtOAc:PE=1:3) affords the target compound (1.68 g, 76.3%). MS: (M+1): 323.2.

Provenance & Evidence