3-ethoxy-N'-hydroxypropanimidamide → {3-[3-(2-Ethoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone

HRID 220020Notes

Reaction equation

HRID 220020 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25]([OH:27])=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH2:28]([O:30][CH2:31][CH2:32][C:33](=[N:35]O)[NH2:34])[CH3:29]>>[CH2:28]([O:30][CH2:31][CH2:32][C:33]1[N:35]=[C:25]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=3)[CH2:14][N:9]([C:7]([N:1]3[CH2:6][CH2:5][S:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[O:27][N:34]=1)[CH3:29]

Participants

3

Reactant 2

HCID 50443873-ethoxy-N'-hydroxypropanimidamideHCID 581165611-(Thiomorpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 59606593{3-[3-(2-Ethoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone

Procedure

According to General Method 6A, 600 mg (1.491 mmol) of the compound from Example 16A and 320 mg (approx. 1.983 mmol) of 3-ethoxy-N′-hydroxypropanimidamide were reacted Yield: 343 mg (46% of theory)

Workup

  1. customwere reacted Yield: 343 mg (46% of theory)

Sources & evidence

ORD record
ord-2acff7741d6d41aca2bb5d80c5a95ded
Source dataset
uspto-grants-2012_06
Patent number
US08202862B2

Reaction notes

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