HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2200205Generated: October 30, 2026
Diisopropylethylamine → HCID 72945587, compound
https://huagongshe.com/reaction/2200205
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 13412530 | HCID 13412530 | — |
| Reactant | HCID 90020675 | HCID 90020675 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 72945587 | HCID 72945587 | 77.1% |
Reaction Steps
Add N-[6-(4-amino-3-methyl-phenoxy)pyrimidin-4-yl]cyclopropanecarboxamide (99 mg, 0.35 mmol), phenyl N-[4-fluoro-3-(trifluoromethyl)phenyl]carbamate (100 mg, 0.35 mmol) and DIEA (135 mg, 1.05 mmol) in THF (4 mL), stir at 80° C. for 2 hrs, Remove the volatiles, suspend the residue in DCM, filter and collect the solid to get the target compound (132 mg, 77%). MS: (M+1): 490.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09359338B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-4c7cf161f18a4d36b8f1534a3d8614ca |
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| Source note | uspto-grants-2016_06 |
|---|
