反应详情

14 g (45 mmol) of methyl 5-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxylate in ethanol (500 ml) were admixed with 17 g of moistened palladium/carbon catalyst (10% palladium, 50% water), and then hydrogenated at 60° C. and a 50 bar hydrogen atmosphere overnight. The reaction solution was filtered, the filter residue was washed with ethanol and the filtrate was concentrated under reduced pressure. The residue was purified by means of column chromatography (silica gel, dichloromethane/methanol 600:1→10:1). Yield: 8 g (59% of theory)

1. customhydrogenated at 60° C.
2. filtrationThe reaction solution was filtered
3. washthe filter residue was washed with ethanol
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was purified by means of column chromatography (silica gel, dichloromethane/methanol 600:1→10:1)