反应详情

温度

100 °C

5-Bromo-6-methylpicolin-imido-hydrazide (1 equiv) and formic acid (15 equiv) were combined and heated to 100° C. for 6 h. The reaction was cooled to room temperature and diluted with methanol. The resulting slurry was partially concentrated under reduced pressure and the resulting mixture was diluted with methanol and partially concentrated under reduced pressure. The resulting solids were collected by filtration, washed with water and dried to provide the desired product, as a solid. MS (ESI) m/z 238.9 [M]+, 240.9 [M+2]+.

1. temperatureThe reaction was cooled to room temperature
2. concentrationThe resulting slurry was partially concentrated under reduced pressure
3. additionthe resulting mixture was diluted with methanol
4. concentrationpartially concentrated under reduced pressure
5. filtrationThe resulting solids were collected by filtration
6. washwashed with water
7. customdried