(Triphenylphosphoranylidene)acetonitrile → HCID 89924005, compound

Participants

Reaction Steps

To the stirred solution of 2-(4-(4-fluorophenyl)piperazin-1-yl)-2-methylpropanal (1.0 g, 4 mmol) in 10 ml of dichloromethane was added 2-(triphenylphosphoranylidene)acetonitrile (1.445 g, 4.8 mmol) at 25° C. The reaction was stirred for 2 days at room temperature. After completion of reaction, the solvent was evaporated to give a crude product. The crude product was purified by column chromatography using 10% ethyl acetate in hexane as an eluent to obtain the title compound (0.7 g, 64.1%).

Provenance & Evidence