HCID 9879259, compound → HCID 118105538, compound

Participants

Reaction Conditions

Reaction Steps

To the stirred solution of 8-benzyl-3-(4-fluorophenyl)-3,8-diazabicyclo[3.2.1]octane (3.5 g, 11.81 mmol) in methanol (30 ml) was added 10% palladium on charcoal (100 mg, 0.940 mmol) at 25° C. The reaction mixture was stirred under hydrogen atmosphere for 3-4 h at 40° C. The reaction mixture was then cooled to 25° C. and filtered through a celite bed. The celite bed was washed with methanol (2×25 ml). The combined filtrate was concentrated under reduced pressure to obtain title compound (2.3 g, 94%).

Provenance & Evidence