Hydrochloric Acid → HCID 136951822, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2′-(3-(4-(4-fluorophenyl)piperazin-1-yl)cyclopent-1-en-1-yl)-7′,8′-dihydro-3′H-spiro[cyclopropane-1,6′-quinazolin]-4′(5′H)-one (550 mg, 1.308 mmol) in dichloromethane (15 ml), and methanol (15 ml) was added hydrochloric acid (2.62 ml, 5.23 mmol, 2M solution in ether) was added at 5-10° C. Reaction mix was stirred at 25° C. for 40-45 mins. Reaction mixture was concentrated under reduced pressure to obtain sticky solid, which was washed with ether (2×10 ml) to afford title compound (0.590 gm).

Provenance & Evidence